Ibuprofen has a low risk of causing serious gastrointestinal (GI) side effects. However, risks do exist and depend on the person's age, duration of use, dosage, and any existing health concerns. can you take ibuprofen on an empty stomach? Be sure to discuss the benefits of ibuprofen and any risks with your doctor before taking this medication. If you have heart, kidney, high blood pressure, or other chronic medical conditions, ask your doctor about the use of ibuprofen.