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Tramadol, a synthetic opioid, is a centrally acting analgesic used to relieve moderate to moderately severe pain. It binds to the μ-opioid receptors in the central nervous system, reducing the perception and emotional response to pain. Tramadol also inhibits the reuptake of norepinephrine and serotonin, enhancing their synaptic concentrations and contributing to its analgesic effects. The onset of action of tramadol is typically within 30 minutes, with a duration of 4-6 hours. It is available in various formulations, including immediate-release tablets, extended-release capsules, and injections.

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